Paul R. Brakeman, MD, PhD

Medical Director, Pediatric Kidney Transplant Program
Pediatric nephrologist

Dr. Paul R. Brakeman is medical director of the UCSF Pediatric Kindney Transplant Program. He specializes in evaluating and treating pediatric dialysis patients and pediatric kidney transplant patients, as well as children with conditions including recurrent urinary tract infections, chronic kidney disease, nephrotic syndrome (marked by symptoms of kidney damage, such as too much protein in the urine) and obstructive nephropathy (a problem with urine flow that affects kidney function).

Brakeman's research is focused on the engineering of renal epithelial cells (the cells that line nephrons, the kidney's functional units) for a bioartificial kidney and also on developing three-dimensional culture systems to study kidney toxicology and injury in the lab.

Brakeman earned his medical degree and doctorate through a combined program at the Johns Hopkins School of Medicine. At UCSF, he completed a residency in pediatrics, serving as chief resident, followed by a fellowship in pediatric nephrology.

Clinics

Kidney Transplant Program
1825 Fourth St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 353-8377
Toll-free: (800) 482-7389

Lupus Program
1825 Fourth St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 353-7337
Fax: (415) 353-2861

Nephrology at Modesto
1444 Florida Ave., Ste. 100
Modesto, CA 95350
Phone: (209) 529-1275
Fax: (209) 529-3464

Pediatric Hypertension Program
1825 Fourth St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 476-2423
Fax: (415) 476-9976

Renal Center
1825 Fourth St., Sixth Floor
San Francisco, CA 94158
Phone: (415) 476-2423

UCSF Pediatric Dialysis Unit
1825 Fourth St., Fifth Floor
San Francisco, CA 94158
Phone: (415) 353-2425
Fax: (415) 353-2768

Conditions & Treatments

More about Paul R. Brakeman

Additional Languages

Spanish

Education

Johns Hopkins School of Medicine, MD 1997

Residencies

UCSF, Pediatrics 2001

Fellowships

UCSF, Pediatric Nephrology 2004

Selected Research and Publications

  1. Wang MK, Chuang KW, Li Y, Gaither T, Brakeman P, Gonzalez L, Brennan J, Baskin LS. Renal function outcomes in pediatric patients with symptomatic reflux into the transplanted kidney treated with redo ureteroneocystostomy. J Pediatr Urol. 2018 Mar 14.
  2. Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK. Afadin orients cell division to position the tubule lumen in developing renal tubules. Development. 2017 10 01; 144(19):3511-3520.
  3. Oates A, Benedict KA, Sun K, Brakeman PR, Lim J, Kim C. Laser acupuncture reduces pain in pediatric kidney biopsies: a randomized controlled trial. Pain. 2017 Jan; 158(1):103-109.
  4. Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells. Biomicrofluidics. 2016 Nov; 10(6):064106.
  5. Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy. ASAIO J. 2016 Mar-Apr; 62(2):169-75.
  6. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43.
  7. Wong T, Matthay KK, Boscardin WJ, Hawkins RA, Brakeman PR, DuBois SG. Acute changes in blood pressure in patients with neuroblastoma treated with ¹³¹I-metaiodobenzylguanidine (MIBG). Pediatr Blood Cancer. 2013 Sep; 60(9):1424-30.
  8. Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM, Reichardt LF, Marciano DK. De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity. Development. 2013 Apr; 140(8):1774-84.
  9. Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol. 2012 Aug; 14(8):838-49.
  10. Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci. 2012 Jun; 15(6):836-44.
  11. Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May; 138(10):2099-109.
  12. Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F564-74.
  13. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep. 2008 Sep; 9(9):923-9.
  14. Liu KD, Brakeman PR. Renal repair and recovery. Crit Care Med. 2008 Apr; 36(4 Suppl):S187-92.
  15. Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats. Anesthesiology. 2008 Mar; 108(3):402-14.
  16. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008 Jan; 121(1):37-45.
  17. Brakeman P. Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease. Adv Urol. 2008; 508949.
  18. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40.
  19. Kim M, Datta A, Brakeman P, Yu W, Mostov KE. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis. J Cell Sci. 2007 Jul 15; 120(Pt 14):2309-17.
  20. Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W. Formation of multicellular epithelial structures. Novartis Found Symp. 2005; 269:193-200; discussion 200-5, 223-30.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.